Scientists have provided unprecedented insight into the presynaptic distribution and profile of mitochondria in the developing and mature calyx of Held. The ability to hear relies on neurons to ...

Interactions of two voltage-gated calcium channels and a pump enable separate control of exocytosis and endocytosis at chemical synapses. Chemical synapses transmit information within the nervous ...

Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat. The study helps find a better drug target for the ...

A new study has revealed how tau – a microtubule-binding protein that is implicated in Alzheimer’s disease – weakens transmission across synapses in the brains of mice When injected into presynaptic ...

In the 1950s, advances in microscopy techniques allowed scientists to visualize synaptic communication between two brain cells for the first time. 1,2 However, many details beyond the general synapse ...