DNTH212 is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell ...
The striking benefits achieved with emerging treatment options for recalcitrant connective tissue diseases offer the ...
The authoritative peer-reviewed source for research, analysis, and advances on the therapeutic role of cytokines and IFNs. Suppressor of Cytokine Signaling (SOCS) 1 is a key negative regulator of ...
Researchers have long focused on the Stimulator of Interferon Genes (STING) pathway, a key component of the innate immune system, as an approach to recruit immune cells to target cancer. However, ...
Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase (IDH) 1 and 2 are found in a large subset of diffusely infiltrating gliomas and subsets of acute ...
KUALA LUMPUR, Malaysia — A new interferon-free drug regimen for the treatment of hepatitis C is safe and effective in treatment-naïve patients and in those who previously had a poor response to ...
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