USB devices are block devices like any other. Linux doesn't care if you install or boot from a SATA disk or a USB disk, it makes no differences in that regard. The only niggle is can be BIOS support, ...
How-To Geek on MSN
I found the perfect portable OS for remote work, and it’s not Windows
I switch between computers a lot, so I use a persistent Linux USB that keeps my workspace consistent anywhere.
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